Meet the 2025 Game Changers

The eight game-changer sessions at the American Physiology Summit feature some of the biggest topics impacting life and health today. Top scientists from around the world will come together to present on these vital issues.

Summit Gradient Rule

Diabetes  |  Xenotransplantation |  Bioelectric Medicine  |  Longevity  |  Maternal Behaviors  |  Sleep and Health  |  Inflammation and Immunology  |  Breathwork

Summit Gradient Rule


The Risks and Rewards of GLP-1 Agonists Beyond Diabetes

This session will discuss how GLP-1 agonists—originally designed to combat diabetes and obesity—are now being investigated for their potential to improve cardiovascular function and reduce opioid addiction. Rick Samson, PhD, DSc, FAPS, and Ann Schreihofer, PhD, FAPS, are the session chairs.

Speakers
 

Karolina Skibicka100Karolina Skibicka, PhD
The Pennsylvania State University

Kieren Mather100Kieren Mather, MD
Eli Lilly and Company


Breakthroughs in Xenotransplantation

This session will explore recent advancements and address significant challenges in xenotransplantation—the use of organs from non-human animals, primarily pigs—as a potential solution to the organ shortage crisis. Farah Sheikh, PhD, is the session chair.

Speakers
 

Kelly Hyndman100Kelly Anne Hyndman, PhD
University of Alabama at Birmingham

Muhammad Mohiuddin100Muhammad Mohiuddin, MD/MBBS, DSc (Hon), FAST
University of Maryland


Bioelectric Medicine: Neural Modulation of Central and Peripheral Function

This session will highlight novel and state-of-the art research that uses electroceutical techniques to modulate central and peripheral organ function and behavior, in health and disease, at the neuronal level. Gordon S. Mitchell, PhD, FAPS, and Irving H. Zucker, PhD, FAPS, are the session chairs.

Speakers
 

Michael Kilgard100Michael Kilgard, PhD
University of Texas at Dallas

Marco Capogrosso100Marco Capogrosso, PhD
Texas Biomedical Device Center


Unlocking Longevity through Advances in Nutrition, Exercise and Epigenetics

This session will highlight new and emerging areas in nutrition, exercise and epigenetics and their influence on the physiology of longevity. We’ll explore how this translates into potential healthspan-extending treatments. Benjamin Miller, PhD, FAPS, and Jennifer Steiner, PhD, are the session chairs.

Speakers
 

Luigi Ferrucci100Luigi Ferrucci, MD, PhD
National Institute on Aging

Game Changers Headshot Frame with FillerRafa DeCabo, PhD
National Institute on Aging

Game Changers Headshot Frame with FillerRozalyn Anderson, PhD
University of Wisconsin


Unraveling the Link between Maternal Behaviors and Offspring Disease

This session will present new findings from basic and clinical research that show how maternal behaviors may affect health outcomes in offspring. Kathryn Hamilton, PhD, and Evangeline Deer, PhD, are the session chairs.

Speakers
 

Kristin Stanford100Kristin Stanford, PhD
The Ohio State University

Tracey Baker 100x100Tracy Baker, PhD
University of Wisconsin-Madison


Circadian Rhythm's Impact on Sleep and Health

This session will discuss how sleep and circadian rhythms interact to influence physiological health, homeostasis and human disease. Josie Broussard, PhD, and Jason Carter, PhD, FAPS, are the session chairs.

Speakers
 

Ketema Paul100Ketema Paul, PhD
UCLA

Kristen Knutson100Kristen Knutson, PhD
Northwestern University Feinberg School of Medicine

Kenneth Wright, PhD
University of Colorado Boulder


Discoveries at the Intersection of Inflammation and Immunology

This session will explore the intricacies of inflammation and immunology. Talks will delve into the cutting-edge intersections of ecoimmunology, the microbiome and immune cell membrane physiology. Denise Cornelius, PhD, and Elaine Lee, PhD, are the session chairs.

Speakers
 

Lynn Martin100Lynn Martin, PhD
University of South Florida

Stefan Feske100Stefan Feske, MD
New York University School of Medicine

Game Changers Headshot Frame with FillerR. Balfour Sartor, MD
University of North Carolina


The Science Behind Breathwork and Why it Matters

This session will explore the mechanisms through which controlled breathing (breathwork) reduces anxiety and inflammation. We'll explore how intermittent exposure to low oxygen environments promotes plasticity. Gordon S. Mitchell, PhD, FAPS is the session chair.

Speakers
 

Alicia Esperanza MeuretAlicia Meuret, PhD
Southern Methodist University

Jack Feldman100Jack Feldman, PhD
David Geffen School of Medicine at UCLA

Randy Trumbower100Randy Trumbower, PT, PhD
Harvard Medical School