Lack of Women as Research Subjects Connected to Lack of Women as Researchers

Review of exercise studies finds gender parity of subjects more likely with female scientists

 

Long Beach, Calif. (April 21, 2023)—The underrepresentation of female research subjects has been documented from clinical trials down to sources for cell cultures. Now, researchers out of Marquette University in Milwaukee have found that in exercise research, this inequity correlates with the gender of the researchers conducting the study. The research team will present their work this week at the American Physiology Summit, the flagship annual meeting of the American Physiological Society (APS), in Long Beach, California.

“Our findings provide direct evidence of the link between gender of authors and gender of research participants.” —Jessica Linde

The dearth of women in research studies has led to gaps in our understanding of how interventions will affect women at the clinical trial stage. Often, a better understanding of how treatments affect the female population doesn’t occur until after they are introduced to the wider public. One high-profile example of this gap came in 2013 when the U.S. Food and Drug Administration (FDA) called for the dosage of Ambien and similar insomnia medications to be cut in half for women because researchers found the active ingredient remained in their bloodstream much longer than had been assumed. The medications had been approved by the FDA at a time when women of childbearing age were discouraged from participating in clinical studies.

In the current study, the team analyzed 971 original research articles that reported findings from human studies in three journals prominent in the field of exercise physiology: Journal of Applied Physiology, Medicine and Science in Sports and Exercise, and British Journal of Sports Medicine. The researchers looked at research published in 1991 and in 2021.

In 1991, 51% of papers were authored by all-male teams—a percentage that declined to 18% in 2021. All female-research teams also declined, from 1.8% in 1991 to 1.1% in 2021. While the number of women participating in exercise studies increased from 1991, in 2021 women still only made up one-third of participants per study.

In both 1991 and 2021, the number of female study participants was lower when the last author of the study—usually the head of the lab conducting the study—was a man. In contrast, when 2021 studies had a woman as the last author, “they include equal numbers of men and women as participants, which is reflective of the population,” Jessica Linde, lead author of the study, said.

The correlation between authorship gender and participant gender grew stronger in 2021. The correlation did not stop with authorship; the team also found that more women in other leadership roles such as editorial board members also correlated to greater gender parity of research subjects in published findings.

The research team concludes that “the low representation of women as participants in exercise science and physiology research could be resolved by encouraging authors who are men to research equitable numbers of each gender.”

NOTE TO JOURNALISTS: The American Physiology Summit will be held April 20–23, 2023, in Long Beach, California. To schedule an interview with the researchers, conference organizers or presenters, contact APS Media Relations or call 301.634.7314. Find more highlights from the meeting in our Summit Newsroom.

Physiology is a broad area of scientific inquiry that focuses on how molecules, cells, tissues and organs function in health and disease. The American Physiological Society connects a global, multidisciplinary community of more than 10,000 biomedical scientists and educators as part of its mission to advance scientific discovery, understand life and improve health. The Society drives collaboration and spotlights scientific discoveries through its 16 scholarly journals and programming that support researchers and educators in their work.