Heat Stress Prompts Kidneys to Tap into Their Reserves

Rockville, Md. (September 22, 2022)—Acute kidney injury—defined as an abrupt decline in glomerular filtration rate (GFR)—is among the top causes of hospitalization during a heat wave. New research published ahead of print in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology sheds light on how heat stress affects kidney function. The study was chosen as an APSselect article for September.

“The findings of the present study support that GFR reserve is utilized to maintain GFR during mild passive heat stress in young healthy adults.”

Under normal conditions, the kidneys have a reserve of untapped function they can draw on in the event of greater physiological need. The capacity to increase function is called the GFR reserve. One way to study GFR reserve is to monitor levels of a waste product called creatinine for a few hours after eating a high-protein meal.

For the current study, 16 healthy adults completed two versions of such a trial, one under normal heat conditions and the other under mild heat stress. After collecting baseline readings of kidney function, researchers gave each participant a whey protein shake and monitored them for two and a half hours.

The research team found that creatinine levels were elevated after drinking the shake in the normal temperature trial but not in the heat stress trial. This indicates that the participants’ kidneys were not able to increase their filtration rate to the same degree when faced with mild heat stress as they did at a normal temperature. They likely used their reserve to maintain a reduced degree of function.

This study sheds light on a likely mechanism for the increase in kidney injury during heat waves. The authors note that those known to be at greater risk for kidney damage during heat waves tend to also be populations known to have reduced GFR reserves, such as older adults.

Read the full article, “Glomerular filtration rate reserve is reduced during mild passive heat stress in healthy young adults,” published ahead of print in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. It is highlighted as one of this month’s “best of the best” as part of the American Physiological Society’s APSselect program. Read all of this month’s selected research articles.

NOTE TO JOURNALISTS: To schedule an interview with a member of the research team, please contact APS Media Relations or call 301.634.7314. Find more research highlights in our Newsroom.

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